Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80156
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1780±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80156
Synonyms:
4-[(1-methyl-2-pyrrolyl)methylideneamino]-3-phenyl-1H-1,2,4-triazole-5-thione | 4-[(1-methylpyrrol-2-yl)methyleneamino]-3-phenyl-1H-1,2,4-triazole-5-thione | 4-[(1-methylpyrrol-2-yl)methylideneamino]-3-phenyl-1H-1,2,4-triazole-5-thione | 4-{[(1-methyl-1H-pyrrol-2-yl)methylene]amino}-5-phenyl-4H-1,2,4-triazole-3-thiol | MLS000573320 | SMR000194822 | cid_668477
Type:
Small organic molecule
Emp. Form.:
C14H13N5S
Mol. Mass.:
283.352
SMILES:
Cn1cccc1C=Nn1c(n[nH]c1=S)-c1ccccc1 |w:7.8|
Structure:
