Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80162
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
2280±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80162
Synonyms:
3-(5-methyl-1H-pyrazol-3-yl)-4-[(5-methyl-2-thienyl)methyleneamino]-1H-1,2,4-triazole-5-thione | 3-(5-methyl-1H-pyrazol-3-yl)-4-[(5-methyl-2-thiophenyl)methylideneamino]-1H-1,2,4-triazole-5-thione | 3-(5-methyl-1H-pyrazol-3-yl)-4-[(5-methylthiophen-2-yl)methylideneamino]-1H-1,2,4-triazole-5-thione | 5-(5-Methyl-2H-pyrazol-3-yl)-4-{[1-(5-methyl-thiophen-2-yl)-meth-(E)-ylidene]-amino}-4H-[1,2,4]triazole-3-thiol | MLS000331397 | SMR000220877 | cid_1401745
Type:
Small organic molecule
Emp. Form.:
C12H12N6S2
Mol. Mass.:
304.394
SMILES:
Cc1cc(n[nH]1)-c1n[nH]c(=S)n1N=Cc1ccc(C)s1 |w:12.13|
Structure:
