Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM60766
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
2290±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM60766
Synonyms:
4-[(E)-3-Furan-2-yl-2-methyl-prop-2-en-(E)-ylideneamino]-5-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl)- 4H-[1,2,4]triazole-3-thiol | 4-[[(E)-3-(2-furanyl)-2-methylprop-2-enylidene]amino]-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-1H-1,2,4-triazole-5-thione | 4-[[(E)-3-(2-furyl)-2-methyl-prop-2-enylidene]amino]-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-1H-1,2,4-triazole-5-thione | 4-[[(E)-3-(furan-2-yl)-2-methyl-prop-2-enylidene]amino]-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-1H-1,2,4-triazole-5-thione | 4-[[(E)-3-(furan-2-yl)-2-methylprop-2-enylidene]amino]-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-1H-1,2,4-triazole-5-thione | MLS000762698 | SMR000438118 | cid_1633723
Type:
Small organic molecule
Emp. Form.:
C16H16N6OS
Mol. Mass.:
340.403
SMILES:
CC(C=Nn1c(n[nH]c1=S)-c1n[nH]c2CCCc12)=Cc1ccco1 |w:3.3,18.21|
Structure:
