Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80315
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1950±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80315
Synonyms:
2-[methyl(8-quinolinylsulfonyl)amino]-N-(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)acetamide | 2-[methyl(8-quinolylsulfonyl)amino]-N-(2-thioxo-3H-1,3,4-thiadiazol-5-yl)acetamide | 2-[methyl(quinolin-8-ylsulfonyl)amino]-N-(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)acetamide | 2-[methyl(quinolin-8-ylsulfonyl)amino]-N-(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)ethanamide | MLS001202374 | N~1~-(5-mercapto-1,3,4-thiadiazol-2-yl)-N~2~-methyl-N~2~-(quinolin-8-ylsulfonyl)glycinamide | SMR000564859 | cid_3620356
Type:
Small organic molecule
Emp. Form.:
C14H13N5O3S3
Mol. Mass.:
395.48
SMILES:
CN(CC(=O)Nc1nnc(S)s1)S(=O)(=O)c1cccc2cccnc12
Structure:
