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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80361
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
1260±73 nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM80361
Synonyms:
5-(diethylamino)-2-hydroximino-valeric acid ethyl ester;iodomethane | 5-(diethylamino)-2-hydroxyiminopentanoic acid ethyl ester;iodomethane | MLS000047831 | SMR000033832 | cid_6411257 | ethyl (2Z)-5-(diethylamino)-2-(hydroxyimino)pentanoate | ethyl 5-(diethylamino)-2-hydroxyimino-pentanoate;iodanylmethane | ethyl 5-(diethylamino)-2-hydroxyiminopentanoate;iodomethane
Type:
Small organic molecule
Emp. Form.:
C11H22N2O3
Mol. Mass.:
230.304
SMILES:
CCOC(=O)C(CCCN(CC)CC)N=O
Structure:
Search PDB for entries with ligand similarity: