Reaction Details
Report a problem with these data
Report a problem with these dataTarget
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80384
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
1810±77 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80384
Synonyms:
2-[N-(benzenesulfonyl)-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide | MLS000110102 | N-(1,3-benzodioxol-5-yl)-2-(N-besyl-2-methoxy-anilino)acetamide | N-(1,3-benzodioxol-5-yl)-2-[(2-methoxyphenyl)-(phenylsulfonyl)amino]ethanamide | SMR000106034 | cid_1138020
Type:
Small organic molecule
Emp. Form.:
C22H20N2O6S
Mol. Mass.:
440.469
SMILES:
COc1ccccc1N(CC(=O)Nc1ccc2OCOc2c1)S(=O)(=O)c1ccccc1
Structure:
