Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80391
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2420±239 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80391
Synonyms:
2-phenylacetic acid [1-(4-methyl-4-morpholin-4-iumyl)-3-phenylmethoxypropan-2-yl] ester;iodide | 2-phenylacetic acid [1-(benzoxymethyl)-2-(4-methylmorpholin-4-ium-4-yl)ethyl] ester;iodide | 4-(3-Benzyloxy-2-phenylacetoxy-propyl)-4-methyl-morpholin-4-ium | MLS000554137 | SMR000146454 | [1-(4-methylmorpholin-4-ium-4-yl)-3-phenylmethoxy-propan-2-yl] 2-phenylethanoate;iodide | [1-(4-methylmorpholin-4-ium-4-yl)-3-phenylmethoxypropan-2-yl] 2-phenylacetate;iodide | cid_9550016
Type:
Small organic molecule
Emp. Form.:
C23H30NO4
Mol. Mass.:
384.4881
SMILES:
C[N+]1(CC(COCc2ccccc2)OC(=O)Cc2ccccc2)CCOCC1
Structure:
