Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80392
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
1990±175 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80392
Synonyms:
1-phenyl-1-cyclopentanecarboxylic acid 3-(4-methyl-4-morpholin-4-iumyl)propyl ester;iodide | 1-phenylcyclopentanecarboxylic acid 3-(4-methylmorpholin-4-ium-4-yl)propyl ester;iodide | 3-(4-methylmorpholin-4-ium-4-yl)propyl 1-phenylcyclopentane-1-carboxylate;iodide | MLS000519370 | SMR000129789 | cid_9550057
Type:
Small organic molecule
Emp. Form.:
C20H30NO3
Mol. Mass.:
332.4566
SMILES:
C[N+]1(CCCOC(=O)C2(CCCC2)c2ccccc2)CCOCC1
Structure:
