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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80413
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2640±242 nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM80413
Synonyms:
(E)-2-cyano-3-(2-methyl-1H-indol-3-yl)-N-(1-phenylethyl)-2-propenamide | (E)-2-cyano-3-(2-methyl-1H-indol-3-yl)-N-(1-phenylethyl)acrylamide | (E)-2-cyano-3-(2-methyl-1H-indol-3-yl)-N-(1-phenylethyl)prop-2-enamide | 2-Cyano-3-(2-methyl-1H-indol-3-yl)-N-(1-phenyl-ethyl)-acrylamide | MLS000553234 | SMR000177561 | cid_5766359
Type:
Small organic molecule
Emp. Form.:
C21H19N3O
Mol. Mass.:
329.3951
SMILES:
CC(NC(=O)C(=C\c1c(C)[nH]c2ccccc12)\C#N)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: