Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM75812
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2100±252 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM75812
Synonyms:
5-[(diethylamino)carbonyl]-2-[2-(1H-indol-3-yl)vinyl]-1-methylpyridinium | MLS000698163 | N,N-diethyl-6-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-3-pyridin-1-iumcarboxamide;iodide | N,N-diethyl-6-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-pyridin-1-ium-3-carboxamide;iodide | N,N-diethyl-6-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methylpyridin-1-ium-3-carboxamide;iodide | N,N-diethyl-6-[(E)-2-(1H-indol-3-yl)vinyl]-1-methyl-pyridin-1-ium-3-carboxamide;iodide | SMR000228465 | cid_15945801
Type:
Small organic molecule
Emp. Form.:
C21H24N3O
Mol. Mass.:
334.4342
SMILES:
CCN(CC)C(=O)c1ccc(\C=C\c2c[nH]c3ccccc23)[n+](C)c1
Structure:
