Reaction Details Report a problem with these data
Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80439
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2240±210 nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM80439
Synonyms:
1,5-diethyl-2-[2-(1H-indol-3-yl)vinyl]pyridinium | 3-[(E)-2-(1,5-diethyl-2-pyridin-1-iumyl)ethenyl]-1H-indole;iodide | 3-[(E)-2-(1,5-diethylpyridin-1-ium-2-yl)ethenyl]-1H-indole;iodide | 3-[(E)-2-(1,5-diethylpyridin-1-ium-2-yl)vinyl]-1H-indole;iodide | MLS000698168 | SMR000228467 | cid_15945818
Type:
Small organic molecule
Emp. Form.:
C19H21N2
Mol. Mass.:
277.3829
SMILES:
CCc1ccc(\C=C\c2c[nH]c3ccccc23)[n+](CC)c1
Structure:
Search PDB for entries with ligand similarity: