Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80464
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2290±334 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80464
Synonyms:
2-(1-methyl-1-piperidin-1-iumyl)acetic acid [2-(2-methylpropyl)cyclohexyl] ester;iodide | 2-(1-methylpiperidin-1-ium-1-yl)acetic acid (2-isobutylcyclohexyl) ester;iodide | MLS000710917 | SMR000280684 | [2-(2-methylpropyl)cyclohexyl] 2-(1-methylpiperidin-1-ium-1-yl)acetate;iodide | [2-(2-methylpropyl)cyclohexyl] 2-(1-methylpiperidin-1-ium-1-yl)ethanoate;iodide | cid_16189443
Type:
Small organic molecule
Emp. Form.:
C18H34NO2
Mol. Mass.:
296.4675
SMILES:
CC(C)CC1CCCCC1OC(=O)C[N+]1(C)CCCCC1
Structure:
