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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80494
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2200±134 nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM80494
Synonyms:
2-(5,6-dichloro-2,3-dimethyl-1-benzimidazol-3-iumyl)acetic acid ethyl ester;iodide | 2-(5,6-dichloro-2,3-dimethyl-benzimidazol-3-ium-1-yl)acetic acid ethyl ester;iodide | MLS000709492 | SMR000286859 | cid_16192968 | ethyl 2-(5,6-dichloro-2,3-dimethylbenzimidazol-3-ium-1-yl)acetate;iodide | ethyl 2-[5,6-bis(chloranyl)-2,3-dimethyl-benzimidazol-3-ium-1-yl]ethanoate;iodide
Type:
Small organic molecule
Emp. Form.:
C13H15Cl2N2O2
Mol. Mass.:
302.176
SMILES:
CCOC(=O)Cn1c(C)[n+](C)c2cc(Cl)c(Cl)cc12
Structure:
Search PDB for entries with ligand similarity: