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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80639
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2230±199 nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM80639
Synonyms:
1-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-4-(4-ethoxyphenoxy)-1-butanone | 1-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]-4-(4-ethoxyphenoxy)butan-1-one | 1-[4-(4-chlorophenyl)sulfonylpiperazino]-4-(4-ethoxyphenoxy)butan-1-one | MLS001159634 | SMR000707584 | cid_24983035
Type:
Small organic molecule
Emp. Form.:
C22H27ClN2O5S
Mol. Mass.:
466.978
SMILES:
CCOc1ccc(OCCCC(=O)N2CCN(CC2)S(=O)(=O)c2ccc(Cl)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: