Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM50998
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
4800±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM50998
Synonyms:
2-[(4-methylphenyl)hydrazo]-3-indolone | 2-[2-(4-methylphenyl)hydrazinyl]indol-3-one | 2-[N'-(p-tolyl)hydrazino]indol-3-one | 2-p-Tolylazo-1H-indol-3-ol | MLS000548261 | SMR000171694 | cid_5760074
Type:
Small organic molecule
Emp. Form.:
C15H13N3O
Mol. Mass.:
251.2832
SMILES:
Cc1ccc(NNC2=Nc3ccccc3C2=O)cc1 |t:7|
Structure:
