Reaction Details Report a problem with these data
Target
Inosine-5-monophosphate dehydrogenase
Ligand
BDBM50294184
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
3.3e+3± 2e+2 nM
Citation
Umejiego, NN; Gollapalli, D; Sharling, L; Volftsun, A; Lu, J; Benjamin, NN; Stroupe, AH; Riera, TV; Striepen, B; Hedstrom, L Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. Chem Biol 15:70-7 (2008) [PubMed] Article
More Info.:
Target
Name:
Inosine-5-monophosphate dehydrogenase
Synonyms:
Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43277.98
Organism:
Cryptosporidium parvum
Description:
Cryptosporidium parvum Iowa II, Q5CPK7
Residue:
402
Sequence:
SNMGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
Inhibitor
Name:
BDBM50294184
Synonyms:
CHEMBL561640 | N-(4-chlorophenyl)-2-phenoxypropanamide | N-(4-chlorophenyl)-2-phenoxypropanamide, A | N-(4-chlorophenyl)-2-phenoxypropanamide, Compound A
Type:
Small organic molecule
Emp. Form.:
C15H14ClNO2
Mol. Mass.:
275.73
SMILES:
CC(Oc1ccccc1)C(=O)Nc1ccc(Cl)cc1