Reaction Details Report a problem with these data
Target
Inosine-5-monophosphate dehydrogenase
Ligand
BDBM81328
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
1.6e+3±0.2 nM
Citation
 Umejiego, NN; Gollapalli, D; Sharling, L; Volftsun, A; Lu, J; Benjamin, NN; Stroupe, AH; Riera, TV; Striepen, B; Hedstrom, L Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. Chem Biol 15:70-7 (2008) [PubMed]  Article 
Target
Name:
Inosine-5-monophosphate dehydrogenase
Synonyms:
Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43277.98
Organism:
Cryptosporidium parvum
Description:
Cryptosporidium parvum Iowa II, Q5CPK7
Residue:
402
Sequence:
SNMGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM81328
Synonyms:
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate, Compound E | methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate, E
Type:
Small organic molecule
Emp. Form.:
C12H11NO3
Mol. Mass.:
217.2206
SMILES:
COC(=O)c1c(C)c(=O)[nH]c2ccccc12
Structure:
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