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Target
Aurora kinase C
Ligand
BDBM81552
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
41±0.0 nM
Citation
 Miduturu, CV; Deng, X; Kwiatkowski, N; Yang, W; Brault, L; Filippakopoulos, P; Chung, E; Yang, Q; Schwaller, J; Knapp, S; King, RW; Lee, JD; Herrgard, S; Zarrinkar, P; Gray, NS High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol 18:868-79 (2011) [PubMed]  Article 
Target
Name:
Aurora kinase C
Synonyms:
AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C
Type:
Enzyme
Mol. Mass.:
35602.43
Organism:
Homo sapiens (Human)
Description:
Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.
Residue:
309
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
  
Inhibitor
Name:
BDBM81552
Synonyms:
Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1 | Scaffold, B54
Type:
Small organic molecule
Emp. Form.:
C24H26N6O2
Mol. Mass.:
430.5022
SMILES:
CN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3)N3CCC(O)CC3)nc12
Structure:
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