Reaction Details Report a problem with these data
Target
p53 binding protein
Ligand
BDBM81634
Substrate
n/a
Meas. Tech.
HDM2 Binding Assay
IC50
3.8e+3±n/a nM
Citation
 Cummings, MD; Schubert, C; Parks, DJ; Calvo, RR; LaFrance, LV; Lattanze, J; Milkiewicz, KL; Lu, T Substituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction. Chem Biol Drug Des 67:201-5 (2006) [PubMed]  Article 
Target
Name:
p53 binding protein
Synonyms:
HDM2 | HDM2-HD1 protein | HDM2-p53 protein | P53 binding protein
Type:
Protein
Mol. Mass.:
10726.49
Organism:
Homo sapiens (Human)
Description:
Q9H4C2
Residue:
98
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM81634
Synonyms:
BZD Scaffold, 4
Type:
Small organic molecule
Emp. Form.:
C24H15F3IN2O4
Mol. Mass.:
579.2871
SMILES:
[O-]C(=O)C(N1C(c2ccc(cc2)C(F)(F)F)C(=O)Nc2ccc(I)cc2C1=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: