Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50297422
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
28±3 nM
Citation
Chimenti, F; Bolasco, A; Manna, F; Secci, D; Chimenti, P; Granese, A; Befani, O; Turini, P; Alcaro, S; Ortuso, F Synthesis and molecular modelling of novel substituted-4,5-dihydro-(1H)-pyrazole derivatives as potent and highly selective monoamine oxidase-A inhibitors. Chem Biol Drug Des 67:206-14 (2006) [PubMed] Article
More Info.:
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
Inhibitor
Name:
BDBM50297422
Synonyms:
1-(3-(2,6-dihydroxyphenyl)-5-m-tolyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone | 4,5-Dihydro-(1H)-pyrazole derivative, 1f | CHEMBL560280
Type:
Small organic molecule
Emp. Form.:
C18H18N2O3
Mol. Mass.:
310.3471
SMILES:
CC(=O)N1N=C(CC1c1cccc(C)c1)c1c(O)cccc1O |c:4|