Ki Summary

Reaction Details

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Target

5-hydroxytryptamine 1D receptor

Ligand

BDBM50027065

Substrate

n/a

0.9±n/a nM

Comments

PDSP_797

Citation

Leonhardt, S; Herrick-Davis, K; Titeler, M Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein. J Neurochem 53:465-71 (1989) [PubMed] Article

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Target

Name:

5-hydroxytryptamine 1D receptor

Synonyms:

5-hydroxytryptamine 1D receptor (5HT1D) | HTR1D

Type:

Protein

Mol. Mass.:

12731.52

Organism:

Bos taurus (Bovine)

Description:

Q8MI13

Residue:

119

Sequence:

SNRSLNATATQGAWDPGTLQALKIALVVLLSIITLATVLSNAFVLTTIFLTRKLHTPANCLIGSLAMTDLLVSILVMPISIAYTTTHTWSFGQLLCDIWLSSDITCCTASILHLCVIAL

Inhibitor

Name:

BDBM50027065

Synonyms:

(5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione | (5'alpha)-5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxoergotaman | 12'-hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione | ERGOTAMINE | Ergotamin

Type:

Small organic molecule

Emp. Form.:

C33H35N5O5

Mol. Mass.:

581.6615

SMILES:

CN1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N[C@]1(C)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O |r,c:4|

Structure: