Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM3034
Substrate
Poly(Glu,Tyr)
Meas. Tech.
TPK assay
IC50
>10000±n/a nM
Citation
 Kleinschroth, J; Hartenstein, J; Rudolph, C; Schachtele, C Novel Indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties. Bioorg Med Chem Lett 5:55-60 (1995)    Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_RAT | Ptpn2 | Tyrosine-Specific Protein Kinase
Type:
Enzyme
Mol. Mass.:
48457.78
Organism:
Mus musculus (mouse)
Description:
Small resting B cells from murine spleen cells were prepared, and the supernatant fraction was used for measuring cytosolic tyrosine kinase activity.
Residue:
416
Sequence:
MSATIEREFEELDAQCRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQSAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTRAVVMLNRTVEKESVKCAQYWPTDDREMVFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGEDVNVKQILLSMRKYRMGLIQTPDQLRFSYMAIIEGAKYTKGDSNIQKRWKELSKEDLSPVCRHSQNRTMTEKYNGKRIGSEDEKLTGLSSKVPDTVEESSESILRKRIREDRKATTAQKVQQMRQRLNETERKRKRWLYWQPILTKMGFVSVILVGALVGWTLLFQLNVLPRLTDT
  
Inhibitor
Name:
BDBM3034
Synonyms:
3-{7,19-dimethoxy-23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-3-yl}propanenitrile | Indolocarbazole deriv. 3b
Type:
Small organic molecule
Emp. Form.:
C26H22N4O3
Mol. Mass.:
438.4779
SMILES:
COc1ccc2n(C)c3c(c4C(=O)NCc4c4c5cc(OC)ccc5n(CCC#N)c34)c2c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Poly(Glu,Tyr)
Synonyms:
n/a
Type:
Random Polymer
Mol. Mass.:
358.43
Organism:
n/a
Description:
The molar ratio of glutamic acid:tyrosine is approximately 4:1. 60 uM ATP (0.3 uCi [gamma-32P]ATP) as co-substrate.
Residue:
3
Sequence:
NA