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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM85330
Substrate
n/a
Ki
9.62±n/a nM
Comments
PDSP_1409
Citation
 Bonhaus, DW; Loury, DN; Jakeman, LB; To, Z; DeSouza, A; Eglen, RM; Wong, EH [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. J Pharmacol Exp Ther 267:961-70 (1993) [PubMed] 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_CAVPO | 5HT3R | HTR3 | HTR3A | Serotonin 3a (5-HT3a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55657.07
Organism:
GUINEA PIG
Description:
5-HT3 HTR3A GUINEA PIG::O70212
Residue:
490
Sequence:
MVLWLQLALLALLLPTSLAQGEVRGKGTAQAHNSTRPALQRLSDHLLADYRKSVRPVRDWRKPTTVSIDAIVYAILSVDEKNQVLTTYIWYRQFWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDKSVFMNQGEWELLGVLTEFLEFSDRESRGSFAEMKFYVVIRRRPLFYAVTLLLPSIFLMIVDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLISVYFVVCMALLVISLAETILIVRLVHKQDLQQPVPLWLRHLVLERIAGLLCLGEQLTSHRGPATLQATKTDDFSGSTLLPAMGNHCGPLGGPQDLEKTSRGRGSPPPPPREASLAMCGLLQELASIRHFLEKREETREVARDWLRVGSVLDKLLFRVYLLAVLAYSITLVTLWSVWHYA
  
Inhibitor
Name:
BDBM85330
Synonyms:
CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron hydrochloride
Type:
Small organic molecule
Emp. Form.:
C18H19N3O
Mol. Mass.:
293.363
SMILES:
Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Structure:
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