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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM25764
Substrate
n/a
Ki
4466.83±n/a nM
Comments
PDSP_277
Citation
 Millan, MJ; Canton, H; Gobert, A; Lejeune, F; Rivet, JM; Bervoets, K; Brocco, M; Widdowson, P; Mennini, T; Audinot, V Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther 268:337-52 (1994) [PubMed] 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT2C | HTR2C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51519.58
Organism:
PIG
Description:
G7ZKZ7
Residue:
457
Sequence:
MVNLRKAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAVRGPVEHSRFNSRTKAIMKIAIVWAISLGVSVPIPVIGLRDEDKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHVLRRQALMLLRGHTEEPPGISLDFLKCCKRNTDEESAANPNQDLNPRRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKVYRRAFSNYLRCNYKADKKPPIRQIPRVAATALSGRELNVNIYRHTNEPVIKKADDNEPGIEMQVENLELPVNPSNVVSERISSV
  
Inhibitor
Name:
BDBM25764
Synonyms:
ALPRENOLOL,(+) | ALPRENOLOL,(-) | Alfeprol | Alpheprol | Alprenolol | CHEMBL266195 | {2-hydroxy-3-[2-(prop-2-en-1-yl)phenoxy]propyl}(propan-2-yl)amine
Type:
Small organic molecule
Emp. Form.:
C15H23NO2
Mol. Mass.:
249.3486
SMILES:
CC(C)NCC(O)COc1ccccc1CC=C
Structure:
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