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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM62099
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
7742±173 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM62099
Synonyms:
2-[5-amino-4-(4-tert-butylphenyl)sulfonyl-1-triazolyl]-N-(2-methylphenyl)acetamide | 2-[5-amino-4-(4-tert-butylphenyl)sulfonyl-triazol-1-yl]-N-(o-tolyl)acetamide | 2-[5-amino-4-(4-tert-butylphenyl)sulfonyltriazol-1-yl]-N-(2-methylphenyl)acetamide | 2-[5-azanyl-4-(4-tert-butylphenyl)sulfonyl-1,2,3-triazol-1-yl]-N-(2-methylphenyl)ethanamide | 2-{5-amino-4-[(4-tert-butylphenyl)sulfonyl]-1H-1,2,3-triazol-1-yl}-N-(2-methylphenyl)acetamide | MLS000586851 | SMR000208781 | cid_15944698
Type:
Small organic molecule
Emp. Form.:
C21H25N5O3S
Mol. Mass.:
427.52
SMILES:
Cc1ccccc1NC(=O)Cn1nnc(c1N)S(=O)(=O)c1ccc(cc1)C(C)(C)C
Structure:
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