Reaction Details Report a problem with these data
Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM50736
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
836±43 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM50736
Synonyms:
6-[(5Z)-4-keto-5-(2-keto-1-methyl-indolin-3-ylidene)-2-thioxo-thiazolidin-3-yl]hexanoic acid | 6-[(5Z)-5-(1-methyl-2-oxidanylidene-indol-3-ylidene)-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid | 6-[(5Z)-5-(1-methyl-2-oxo-3-indolylidene)-4-oxo-2-sulfanylidene-3-thiazolidinyl]hexanoic acid | 6-[(5Z)-5-(1-methyl-2-oxoindol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid | 6-{5-[1-Methyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-hexanoic acid | MLS000777256 | SMR000413651 | cid_1560327
Type:
Small organic molecule
Emp. Form.:
C18H18N2O4S2
Mol. Mass.:
390.477
SMILES:
CN1C(=O)\C(=C2/SC(=S)N(CCCCCC(O)=O)C2=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: