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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM43498
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
39331±692 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM43498
Synonyms:
1,1-bis(oxidanylidene)-2-(phenylmethyl)-3,4-dihydro-1,2-benzothiazepin-5-one | 1,1-dioxo-2-(phenylmethyl)-3,4-dihydro-1,2-benzothiazepin-5-one | 2-benzyl-1,1-diketo-3,4-dihydro-1,2-benzothiazepin-5-one | 2-benzyl-1,1-dioxo-3,4-dihydro-1,2-benzothiazepin-5-one | MLS000879339 | SMR000465155 | cid_16060207
Type:
Small organic molecule
Emp. Form.:
C16H15NO3S
Mol. Mass.:
301.36
SMILES:
O=C1CCN(Cc2ccccc2)S(=O)(=O)c2ccccc12
Structure:
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