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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM53091
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
36102±3185 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM53091
Synonyms:
(2E)-5-nitro-6-oxidanyl-2-[(2Z)-2-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)ethylidene]-1H-pyrimidin-4-one | (2E)-6-hydroxy-2-[(2Z)-2-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)ethylidene]-5-nitro-1H-pyrimidin-4-one | (2E)-6-hydroxy-2-[(2Z)-2-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)ethylidene]-5-nitro-1H-pyrimidin-4-one | (2E)-6-hydroxy-2-[(2Z)-2-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-5-nitro-1H-pyrimidin-4-one | 2-[(Z)-2-(3,4-Dihydroxy-phenyl)-vinyl]-6-hydroxy-5-nitro-3H-pyrimidin-4-one | MLS001201374 | SMR000524347 | cid_25043520
Type:
Small organic molecule
Emp. Form.:
C12H9N3O6
Mol. Mass.:
291.2164
SMILES:
Oc1[nH+]c(\C=C\[c-]2ccc(=O)c(O)c2)[nH]c(=O)c1[N+]([O-])=O
Structure:
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