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Target
Beta-lactamase
Ligand
BDBM51704
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA)
IC50
3732±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM51704
Synonyms:
(2S)-2-[(4-methylphenyl)sulfonylamino]-2-phenylacetic acid [2-oxo-4-(trifluoromethyl)-1-benzopyran-7-yl] ester | (2S)-2-phenyl-2-(tosylamino)acetic acid [2-keto-4-(trifluoromethyl)chromen-7-yl] ester | 2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl {[(4-methylphenyl)sulfonyl]amino}(phenyl)acetate | MLS000575791 | SMR000196826 | [2-oxidanylidene-4-(trifluoromethyl)chromen-7-yl] (2S)-2-[(4-methylphenyl)sulfonylamino]-2-phenyl-ethanoate | [2-oxo-4-(trifluoromethyl)chromen-7-yl] (2S)-2-[(4-methylphenyl)sulfonylamino]-2-phenylacetate | cid_1326324
Type:
Small organic molecule
Emp. Form.:
C25H18F3NO6S
Mol. Mass.:
517.474
SMILES:
Cc1ccc(cc1)S(=O)(=O)N[C@H](C(=O)Oc1ccc2c(cc(=O)oc2c1)C(F)(F)F)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: