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Target
Beta-lactamase
Ligand
BDBM83232
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA)
IC50
4695±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM83232
Synonyms:
4-N-benzyl-6-morpholin-4-yl-2-N-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-1,3,5-triazine-2,4-diamine | 6-(4-morpholinyl)-N2-[[5-(4-nitrophenyl)-2-furanyl]methylideneamino]-N4-(phenylmethyl)-1,3,5-triazine-2,4-diamine | 6-morpholin-4-yl-N2-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-N4-(phenylmethyl)-1,3,5-triazine-2,4-diamine | MLS000709332 | SMR000289999 | benzyl-[4-morpholino-6-[N'-[[5-(4-nitrophenyl)-2-furyl]methylene]hydrazino]-s-triazin-2-yl]amine | cid_3100109
Type:
Small organic molecule
Emp. Form.:
C25H24N8O4
Mol. Mass.:
500.5093
SMILES:
[O-][N+](=O)c1ccc(cc1)-c1ccc(CN=Nc2nc(NCc3ccccc3)nc(n2)N2CCOCC2)o1 |w:15.16|
Structure:
Search PDB for entries with ligand similarity: