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Target
Beta-lactamase
Ligand
BDBM83252
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA)
IC50
3785±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM83252
Synonyms:
3-amino-6-(4-chlorophenyl)-4-phenyl-2-furo[2,3-b]pyridinecarbohydrazide | 3-amino-6-(4-chlorophenyl)-4-phenyl-furo[2,3-b]pyridine-2-carbohydrazide | 3-amino-6-(4-chlorophenyl)-4-phenylfuro[2,3-b]pyridine-2-carbohydrazide | 3-azanyl-6-(4-chlorophenyl)-4-phenyl-furo[2,3-b]pyridine-2-carbohydrazide | MLS001181949 | SMR000567620 | cid_2815150
Type:
Small organic molecule
Emp. Form.:
C20H15ClN4O2
Mol. Mass.:
378.812
SMILES:
NNC(=O)c1oc2nc(cc(-c3ccccc3)c2c1N)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: