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Target
Beta-lactamase
Ligand
BDBM83273
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA)
IC50
2744±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM83273
Synonyms:
2-[2-[(Z)-indol-3-ylidenemethyl]hydrazinyl]-N-(2-methoxyphenyl)-5-nitro-benzenesulfonamide | 2-[2-[(Z)-indol-3-ylidenemethyl]hydrazinyl]-N-(2-methoxyphenyl)-5-nitrobenzenesulfonamide | 2-[N'-[(Z)-indol-3-ylidenemethyl]hydrazino]-N-(2-methoxyphenyl)-5-nitro-benzenesulfonamide | 2-[[(Z)-3-indolylidenemethyl]hydrazo]-N-(2-methoxyphenyl)-5-nitrobenzenesulfonamide | MLS002637164 | SMR000155381 | cid_6514766
Type:
Small organic molecule
Emp. Form.:
C22H19N5O5S
Mol. Mass.:
465.482
SMILES:
COc1ccccc1NS(=O)(=O)c1cc(ccc1N=[NH+]Cc1c[n-]c2ccccc12)[N+]([O-])=O |w:18.19|
Structure:
Search PDB for entries with ligand similarity: