Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM34565
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM34565
Synonyms:
6-Amino-4-(4-hydroxy-3,5-dimethoxy-phenyl)-3-methoxymethyl-2,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile | 6-amino-4-(4-hydroxy-3,5-dimethoxy-phenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | 6-amino-4-(4-hydroxy-3,5-dimethoxyphenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | 6-azanyl-4-(3,5-dimethoxy-4-oxidanyl-phenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | MLS000033666 | SMR000014567 | cid_647209
Type:
Small organic molecule
Emp. Form.:
C17H18N4O5
Mol. Mass.:
358.3486
SMILES:
COCc1n[nH]c2OC(=N)C(C#N)C(c12)c1cc(OC)c(O)c(OC)c1
Structure:
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