Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83474
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83474
Synonyms:
(6E)-6-[4-(2-furanylmethylamino)-1H-quinazolin-2-ylidene]-1-cyclohexa-2,4-dienone | (6E)-6-[4-(2-furfurylamino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one | (6E)-6-[4-(furan-2-ylmethylamino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one | MLS000081088 | SMR000043294 | cid_5389551
Type:
Small organic molecule
Emp. Form.:
C19H15N3O2
Mol. Mass.:
317.3413
SMILES:
Oc1ccccc1-c1nc(NCc2ccco2)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: