Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM50806
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM50806
Synonyms:
2-cyano-2-[3-(diethylamino)-2-quinoxalinyl]-N-(2-phenylethyl)acetamide | 2-cyano-2-[3-(diethylamino)quinoxalin-2-yl]-N-(2-phenylethyl)acetamide | 2-cyano-2-[3-(diethylamino)quinoxalin-2-yl]-N-(2-phenylethyl)ethanamide | 2-cyano-2-[3-(diethylamino)quinoxalin-2-yl]-N-phenethyl-acetamide | MLS000083208 | SMR000048138 | cid_666840
Type:
Small organic molecule
Emp. Form.:
C23H25N5O
Mol. Mass.:
387.4775
SMILES:
CCN(CC)c1nc2ccccc2nc1C(C#N)C(=O)NCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: