Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83478
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83478
Synonyms:
MLS000057525 | N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide | N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide | N-[4-(2-chlorophenyl)-2-thiazolyl]-2-(1,3-dimethyl-2,6-dioxo-7-purinyl)acetamide | N-[4-(2-chlorophenyl)thiazol-2-yl]-2-(2,6-diketo-1,3-dimethyl-purin-7-yl)acetamide | SMR000064223 | cid_2997571
Type:
Small organic molecule
Emp. Form.:
C18H15ClN6O3S
Mol. Mass.:
430.868
SMILES:
Cn1c2ncn(CC(=O)Nc3nc(cs3)-c3ccccc3Cl)c2c(=O)n(C)c1=O
Structure:
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