Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83480
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83480
Synonyms:
5-[2-(6-hydroxy-3-methyl-2-benzofuranyl)-2-oxoethyl]-2-furancarboxylic acid ethyl ester | 5-[2-(6-hydroxy-3-methyl-benzofuran-2-yl)-2-keto-ethyl]furan-2-carboxylic acid ethyl ester | MLS000055045 | SMR000065855 | cid_854591 | ethyl 5-[2-(3-methyl-6-oxidanyl-1-benzofuran-2-yl)-2-oxidanylidene-ethyl]furan-2-carboxylate | ethyl 5-[2-(6-hydroxy-3-methyl-1-benzofuran-2-yl)-2-oxoethyl]furan-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H16O6
Mol. Mass.:
328.316
SMILES:
CCOC(=O)c1ccc(CC(=O)c2oc3cc(O)ccc3c2C)o1
Structure:
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