Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83484
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83484
Synonyms:
5-[[3-(3,5-dimethyl-1-pyrazolyl)-2-quinoxalinyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2-yl]amino]-1,3-dihydrobenzimidazol-2-one | 5-{[3-(3,5-dimethyl-1H-pyrazol-1-yl)-2-quinoxalinyl]amino}-1,3-dihydro-2H-benzimidazol-2-one | MLS000052022 | SMR000081300 | cid_1250673
Type:
Small organic molecule
Emp. Form.:
C20H17N7O
Mol. Mass.:
371.3953
SMILES:
Cc1cc(C)n(n1)-c1nc2ccccc2nc1Nc1ccc2[nH]c(=O)[nH]c2c1
Structure:
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