Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83485
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83485
Synonyms:
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(5-phenyl-3-thiazolo[2,3-c][1,2,4]triazolyl)thio]ethanone | 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(5-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)sulfanyl]ethanone | 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio]ethanone | MLS000115250 | SMR000092412 | cid_1289729
Type:
Small organic molecule
Emp. Form.:
C20H15N3O3S2
Mol. Mass.:
409.481
SMILES:
O=C(CSc1nnc2scc(-c3ccccc3)n12)c1ccc2OCCOc2c1
Structure:
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