Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83487
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
18000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83487
Synonyms:
2-[[2-keto-2-(2-thienyl)ethyl]thio]-4,6-dimethyl-nicotinonitrile | 4,6-dimethyl-2-(2-oxidanylidene-2-thiophen-2-yl-ethyl)sulfanyl-pyridine-3-carbonitrile | 4,6-dimethyl-2-(2-oxo-2-thiophen-2-ylethyl)sulfanylpyridine-3-carbonitrile | 4,6-dimethyl-2-[(2-oxo-2-thiophen-2-ylethyl)thio]-3-pyridinecarbonitrile | MLS000105860 | SMR000102835 | cid_685878
Type:
Small organic molecule
Emp. Form.:
C14H12N2OS2
Mol. Mass.:
288.388
SMILES:
Cc1cc(C)c(C#N)c(SCC(=O)c2cccs2)n1
Structure:
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