Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM40112
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM40112
Synonyms:
1-[1-[2-(4-chloranylphenoxy)ethyl]-2-methyl-indol-3-yl]-N-(1,2,4-triazol-4-yl)methanimine | 1-[1-[2-(4-chlorophenoxy)ethyl]-2-methyl-3-indolyl]-N-(1,2,4-triazol-4-yl)methanimine | 1-[1-[2-(4-chlorophenoxy)ethyl]-2-methylindol-3-yl]-N-(1,2,4-triazol-4-yl)methanimine | MLS000111687 | SMR000107609 | [1-[2-(4-chlorophenoxy)ethyl]-2-methyl-indol-3-yl]methylene-(1,2,4-triazol-4-yl)amine | cid_1335317
Type:
Small organic molecule
Emp. Form.:
C20H18ClN5O
Mol. Mass.:
379.843
SMILES:
Cc1c(C=Nn2cnnc2)c2ccccc2n1CCOc1ccc(Cl)cc1 |w:4.4|
Structure:
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