Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM61015
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM61015
Synonyms:
3-(4-fluorophenyl)-7,8-dimethoxy-5-(phenylmethyl)pyrazolo[4,3-c]quinoline | 5-benzyl-3-(4-fluorophenyl)-7,8-dimethoxy-pyrazolo[4,3-c]quinoline | 5-benzyl-3-(4-fluorophenyl)-7,8-dimethoxypyrazolo[4,3-c]quinoline | MLS000530082 | SMR000127107 | cid_2136878
Type:
Small organic molecule
Emp. Form.:
C25H20FN3O2
Mol. Mass.:
413.4436
SMILES:
COc1cc2n(Cc3ccccc3)cc3c(nnc3c2cc1OC)-c1ccc(F)cc1
Structure:
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