Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83529
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83529
Synonyms:
(4E)-4-[(1-acetyl-3-indolyl)methylidene]-2-phenyl-5-oxazolone | (4E)-4-[(1-acetylindol-3-yl)methylene]-2-phenyl-2-oxazolin-5-one | (4E)-4-[(1-acetylindol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one | (4E)-4-[(1-ethanoylindol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one | 4-(1-Acetyl-1H-indol-3-ylmethylene)-2-phenyl-4H-oxazol-5-one | MLS000557203 | SMR000174534 | cid_695432
Type:
Small organic molecule
Emp. Form.:
C20H14N2O3
Mol. Mass.:
330.3368
SMILES:
CC(=O)n1cc(\C=C2\N=C(OC2=O)c2ccccc2)c2ccccc12 |c:8|
Structure:
Search PDB for entries with ligand similarity: