Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM52437
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM52437
Synonyms:
3-Ethyl-2-[2-(2-methyl-1H-indol-3-yl)-vinyl]-3H-quinazolin-4-one | 3-ethyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-4-quinazolinone | 3-ethyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one | 3-ethyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)vinyl]quinazolin-4-one | MLS000566893 | SMR000176456 | cid_5761675
Type:
Small organic molecule
Emp. Form.:
C21H19N3O
Mol. Mass.:
329.3951
SMILES:
CCn1c(\C=C\c2c(C)[nH]c3ccccc23)nc2ccccc2c1=O
Structure:
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