Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83547
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
10400±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83547
Synonyms:
(E)-2-(4-cyclopropyl-1,3-thiazol-2-yl)-3-(4-nitrophenyl)prop-2-enenitrile | (E)-2-(4-cyclopropyl-2-thiazolyl)-3-(4-nitrophenyl)-2-propenenitrile | (E)-2-(4-cyclopropylthiazol-2-yl)-3-(4-nitrophenyl)acrylonitrile | 2-(4-Cyclopropyl-thiazol-2-yl)-3-(4-nitro-phenyl)-acrylonitrile | MLS000569222 | SMR000176198 | cid_5720699
Type:
Small organic molecule
Emp. Form.:
C15H11N3O2S
Mol. Mass.:
297.332
SMILES:
[O-][N+](=O)c1ccc(\C=C(/C#N)c2nc(cs2)C2CC2)cc1
Structure:
Search PDB for entries with ligand similarity: