Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83242
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
12000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83242
Synonyms:
MLS000859743 | SMR000459122 | [4-amino-3-(2-piperidin-1-ylethylsulfanyl)thieno[2,3-c][1,2]thiazol-5-yl]-thiophen-2-ylmethanone | [4-amino-3-(2-piperidinoethylthio)thien[2,3-c]isothiazol-5-yl]-(2-thienyl)methanone | [4-amino-3-[2-(1-piperidinyl)ethylthio]-5-thieno[2,3-c]isothiazolyl]-thiophen-2-ylmethanone | [4-azanyl-3-(2-piperidin-1-ylethylsulfanyl)thieno[2,3-c][1,2]thiazol-5-yl]-thiophen-2-yl-methanone | cid_2816883 | {4-amino-3-[(2-piperidinoethyl)sulfanyl]thieno[2,3-c]isothiazol-5-yl}(2-thienyl)methanone
Type:
Small organic molecule
Emp. Form.:
C17H19N3OS4
Mol. Mass.:
409.612
SMILES:
Nc1c(sc2nsc(SCCN3CCCCC3)c12)C(=O)c1cccs1
Structure:
Search PDB for entries with ligand similarity: