Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM50771
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
11400±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM50771
Synonyms:
3-(5-methylfuran-2-yl)carbonyl-4-oxidanyl-2-(3-prop-2-enoxyphenyl)-1-(1,3-thiazol-2-yl)-2H-pyrrol-5-one | 4-hydroxy-3-(5-methylfuran-2-carbonyl)-2-(3-prop-2-enoxyphenyl)-1-(1,3-thiazol-2-yl)-2H-pyrrol-5-one | 4-hydroxy-3-[(5-methyl-2-furanyl)-oxomethyl]-2-(3-prop-2-enoxyphenyl)-1-(2-thiazolyl)-2H-pyrrol-5-one | 5-(3-Allyloxy-phenyl)-3-hydroxy-4-(5-methyl-furan-2-carbonyl)-1-thiazol-2-yl-1,5-dihydro-pyrrol-2-one | 5-(3-allyloxyphenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-thiazol-2-yl-3-pyrrolin-2-one | MLS000033775 | SMR000013770 | cid_654648
Type:
Small organic molecule
Emp. Form.:
C22H18N2O5S
Mol. Mass.:
422.454
SMILES:
Cc1ccc(o1)C(=O)C1C(N(C(=O)C1=O)c1nccs1)c1cccc(OCC=C)c1
Structure:
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