Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83721
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
1140±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83721
Synonyms:
6,7-dichloro-2-hydroxy-1,1-diketo-3-(2-keto-2-methoxy-ethyl)-4H-1,2,4-benzothiadiazine-3-carboxylic acid methyl ester | 6,7-dichloro-2-hydroxy-3-(2-methoxy-2-oxoethyl)-1,1-dioxo-4H-1,2,4-benzothiadiazine-3-carboxylic acid methyl ester | MLS002920772 | SMR001798358 | cid_294721 | methyl 6,7-bis(chloranyl)-3-(2-methoxy-2-oxidanylidene-ethyl)-2-oxidanyl-1,1-bis(oxidanylidene)-4H-1,2,4-benzothiadiazine-3-carboxylate | methyl 6,7-dichloro-2-hydroxy-3-(2-methoxy-2-oxoethyl)-1,1-dioxo-4H-1,2,4-benzothiadiazine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C12H12Cl2N2O7S
Mol. Mass.:
399.204
SMILES:
COC(=O)CC1(Nc2cc(Cl)c(Cl)cc2S(=O)(=O)N1O)C(=O)OC
Structure:
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