Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM77499
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
7390±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM77499
Synonyms:
2-(2-Methoxy-phenylamino)-8-methyl-quinoline-3-carbonitrile | 2-(2-methoxyanilino)-8-methyl-3-quinolinecarbonitrile | 2-(2-methoxyanilino)-8-methylquinoline-3-carbonitrile | 2-[(2-methoxyphenyl)amino]-8-methyl-quinoline-3-carbonitrile | 8-methyl-2-(o-anisidino)quinoline-3-carbonitrile | MLS000551998 | SMR000172503 | cid_865262
Type:
Small organic molecule
Emp. Form.:
C18H15N3O
Mol. Mass.:
289.3312
SMILES:
COc1ccccc1Nc1nc2c(C)cccc2cc1C#N
Structure:
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