Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM33110
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
5480±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM33110
Synonyms:
5-[(6-Bromo-2-hydroxy-naphthalen-1-ylmethylene)-amino]-1,3-dihydro-benzoimidazol-2-one | 5-[[(E)-(6-bromo-2-keto-1-naphthylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(Z)-(6-bromanyl-2-oxidanylidene-naphthalen-1-ylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(Z)-(6-bromo-2-keto-1-naphthylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(Z)-(6-bromo-2-oxo-1-naphthalenylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(Z)-(6-bromo-2-oxonaphthalen-1-ylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | MLS000553451 | SMR000171789 | cid_5761516
Type:
Small organic molecule
Emp. Form.:
C18H12BrN3O2
Mol. Mass.:
382.211
SMILES:
Oc1ccc2cc(Br)ccc2c1C=Nc1ccc2[nH]c(=O)[nH]c2c1 |w:13.15|
Structure:
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